Article-Journal

TCM-Navigator: A deep learning workflow for TCM-like compound generation and evaluation featured image
AI-Driven Drug Discovery

TCM-Navigator: A deep learning workflow for TCM-like compound generation and evaluation

Built an end-to-end AI workflow that generated 3.7 million TCM-like molecules, supports target-specific generation, and links molecular generation to TCM-like quality control and …

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Feiying Chen
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In silico Identification and Experimental Validation of Long-range Allosteric Inhibition of Staphylococcus aureus Cas9 by Anti-CRISPR Protein AcrIIA14 featured image
CRISPR-Cas9

In silico Identification and Experimental Validation of Long-range Allosteric Inhibition of Staphylococcus aureus Cas9 by Anti-CRISPR Protein AcrIIA14

Combined computation and experiments to map remote allosteric inhibition of SauCas9 by AcrIIA14, highlighting dynamic inhibitory states and potential routes for allosteric Cas9 …

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Feiying Chen
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Allostery

ASD2023: Toward an integrated allosteric knowledgebase

Contributed to the ASD2023 database update, which organizes allosteric sites, PPI modulators, hit-to-lead examples, and dualsteric modulators for target identification and …

jixiao-he
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